The 2022 NFL season showcased some remarkable performances, as teams battled it out in the ATS (Against The Spread), SU (Straight Up), and O/U (Over/Under) standings. The Kansas City Chiefs led the way with an impressive 17-3 SU record, while the Philadelphia Eagles excelled with a 16-4 SU record. The San Francisco 49ers boasted a solid 13-7 ATS standing, and the Cincinnati Bengals dominated with a 15-5 ATS record. It was a thrilling season with plenty of surprises and standout performances across the league.
| No. | Teams | Overall | Home | Road | ||||||
| OVERALL SU | OVERALL ATS | OVERALL O/U | HOME SU | HOME ATS | HOME O/U | ROAD SU | ROAD ATS | ROAD O/U | ||
| 1 | KANSAS CITY CHIEFS (A) | 17-3 | 9-11 | 9-11-0 | 9-1 | 4-6 | 2-8-0 | 8-2 | 5-5 | 7-3-0 |
| 2 | PHILADELPHIA EAGLES (A) | 16-4 | 10-10 | 11-9-0 | 9-3 | 8-4 | 7-5-0 | 7-1 | 2-6 | 4-4-0 |
| 3 | SAN FRANCISCO 49ERS (A) | 15-5 | 13-7 | 10-10-0 | 10-1 | 9-2 | 6-5-0 | 5-4 | 4-5 | 4-5-0 |
| 4 | CINCINNATI BENGALS (A) | 15-5 | 15-5 | 8-12-0 | 8-1 | 7-2 | 4-5-0 | 7-4 | 8-3 | 4-7-0 |
| 5 | BUFFALO BILLS (A) | 14-5 | 8-11 | 7-12-0 | 8-2 | 4-6 | 6-4-0 | 6-3 | 4-5 | 1-8-0 |
| 6 | MINNESOTA VIKINGS (A) | 13-5 | 7-11 | 12-6-0 | 8-2 | 4-6 | 8-2-0 | 5-3 | 3-5 | 4-4-0 |
| 7 | DALLAS COWBOYS (A) | 13-6 | 11-8 | 8-11-0 | 8-1 | 6-3 | 5-4-0 | 5-5 | 5-5 | 3-7-0 |
| 8 | LOS ANGELES CHARGERS (B) | 10-8 | 12-6 | 8-9-1 | 5-3 | 5-3 | 3-4-1 | 5-5 | 7-3 | 5-5-0 |
| 9 | NEW YORK GIANTS (B) | 10-8 | 13-5 | 7-12-0 | 5-3 | 5-3 | 3-6-0 | 5-5 | 8-2 | 4-6-0 |
| 10 | JACKSONVILLE JAGUARS (B) | 10-9 | 10-9 | 8-10-1 | 6-3 | 5-4 | 3-6-0 | 4-6 | 5-5 | 5-4-1 |
| 11 | BALTIMORE RAVENS (B) | 10-8 | 8-10 | 6-12-0 | 5-3 | 2-6 | 1-7-0 | 5-5 | 6-4 | 5-5-0 |
| 12 | SEATTLE SEAHAWKS (B) | 9-9 | 7-11 | 9-9-0 | 5-4 | 4-5 | 3-6-0 | 4-5 | 3-6 | 6-3-0 |
| 13 | MIAMI DOLPHINS (B) | 9-9 | 10-8 | 9-9-0 | 6-2 | 5-3 | 1-7-0 | 3-7 | 5-5 | 8-2-0 |
| 14 | PITTSBURGH STEELERS (B) | 9-8 | 10-7 | 7-10-0 | 4-4 | 4-4 | 3-5-0 | 5-4 | 6-3 | 4-5-0 |
| 15 | DETROIT LIONS (B) | 9-8 | 12-5 | 10-7-0 | 5-4 | 7-2 | 6-3-0 | 4-4 | 5-3 | 4-4-0 |
| 16 | GREEN BAY PACKERS (C) | 8-9 | 8-9 | 8-9-0 | 5-4 | 4-5 | 5-4-0 | 3-5 | 4-4 | 3-5-0 |
| 17 | TAMPA BAY BUCCANEERS (C) | 8-10 | 4-14 | 6-12-0 | 5-5 | 2-8 | 4-6-0 | 3-5 | 2-6 | 2-6-0 |
| 18 | WASHINGTON COMMANDERS (B) | 8-8 | 9-7 | 5-12-0 | 4-5 | 5-4 | 2-7-0 | 4-3 | 4-3 | 3-5-0 |
| 19 | NEW ENGLAND PATRIOTS (C) | 8-9 | 8-9 | 8-9-0 | 4-4 | 3-5 | 3-5-0 | 4-5 | 5-4 | 5-4-0 |
| 20 | NEW YORK JETS (C) | 7-10 | 8-9 | 5-12-0 | 3-5 | 3-5 | 2-6-0 | 4-5 | 5-4 | 3-6-0 |
| 21 | CLEVELAND BROWNS (C) | 7-10 | 8-9 | 9-8-0 | 4-4 | 4-4 | 5-3-0 | 3-6 | 4-5 | 4-5-0 |
| 22 | ATLANTA FALCONS (C) | 7-10 | 9-8 | 7-10-0 | 6-3 | 5-4 | 4-5-0 | 1-7 | 4-4 | 3-5-0 |
| 23 | NEW ORLEANS SAINTS (C) | 7-10 | 7-10 | 6-11-0 | 4-5 | 4-5 | 4-5-0 | 3-5 | 3-5 | 2-6-0 |
| 24 | CAROLINA PANTHERS (C) | 7-10 | 9-8 | 8-9-0 | 5-4 | 5-4 | 4-5-0 | 2-6 | 4-4 | 4-4-0 |
| 25 | TENNESSEE TITANS (C) | 7-10 | 9-8 | 5-12-0 | 3-5 | 3-5 | 2-6-0 | 4-5 | 6-3 | 3-6-0 |
| 26 | LAS VEGAS RAIDERS (C) | 6-11 | 8-9 | 8-9-0 | 4-4 | 5-3 | 5-3-0 | 2-7 | 3-6 | 3-6-0 |
| 27 | Los Angeles Rams (C) | 5-12 | 7-10 | 7-10-0 | 4-5 | 4-5 | 5-4-0 | 1-7 | 3-5 | 2-6-0 |
| 28 | DENVER BRONCOS (C) | 5-12 | 7-10 | 6-11-0 | 4-4 | 3-5 | 3-5-0 | 1-8 | 4-5 | 3-6-0 |
| 29 | INDIANAPOLIS COLTS (C) | 4-12 | 6-10 | 7-10-0 | 2-6 | 3-5 | 3-5-0 | 2-6 | 3-5 | 4-5-0 |
| 30 | ARIZONA CARDINALS (C) | 4-13 | 8-9 | 9-8-0 | 1-8 | 4-5 | 5-4-0 | 3-5 | 4-4 | 4-4-0 |
| 31 | CHICAGO BEARS (C) | 3-14 | 5-12 | 10-7-0 | 2-7 | 3-6 | 5-4-0 | 1-7 | 2-6 | 5-3-0 |
| 32 | HOUSTON TEXANS (C) | 3-13 | 8-8 | 7-10-0 | 0-7 | 2-5 | 3-5-0 | 3-6 | 6-3 | 4-5-0 |